One of the injured officers was taken in a police car to the hospital. Officials said emergency medical teams were transporting the other.
The accident occurred 100 yards from the building entrance on the Senate side of the Capitol building. The fence blocking vehicle traffic near that area was removed recently as the Capitol has yet to open up Riots January 6.
Senators and employees usually use the security checkpoint on weekdays. Congress is currently on recess.
A video posted online showed a dark colored sedan crashing in front of a barricade and K9 police scanning the vehicle.
Law enforcement and paramedics can be seen caring for at least one unidentified individual.
Joe Biden had just left the White House for Camp David When the accident happened. As usual, he was traveling with a member of the National Security Council who was expected to brief him on the incident.