Rafael Nadal will miss the US Open after the Spaniard ended the 2021 season with a foot injury.
An injury caused the 20-times Grand Slam winner to miss the Cincinnati Masters and Canadian Open last week.
Defending champion Dominic Thiem and five-time winner Roger Federer have also pulled out of this year’s US Open.
“Honestly, I’ve suffered more than I should have with my feet in a year and I need some time off,” Nadal, 35, wrote on Instagram.
He added: “After discussing it with the team and family, this decision has been made and I think it’s the way forward to try to recover and recover well.
“Wellness and access [determined] To do whatever it takes to get back in the best shape possible, to keep competing for the things that really motivate me and the things I’ve done over all these years.
“I am convinced that with the recovery of the foot it is clear that this can be achieved with a very important daily effort. I will work as hard as I can to make it happen.”
The four-time US Open champion didn’t compete at Wimbledon or the Olympics to rest after the clay court season.
He was injured at the French Open in June, failing to defend his title for the first time since 2016 with a semi-final defeat to Novak Djokovic.
Federer and Nadal are tied with world number one Novak Djokovic, who will be looking to complete the Grand Slam schedule at Flushing Meadows, to score 20 grand slam titles.