COVID-19 mRNA and myocarditis vaccines: benefits outweigh risks, says WHO panel |


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Myocarditis is inflammation of the heart muscle and pericarditis is an inflammation of the lining that surrounds the heart. While it can result from serious illness, cases are often mild and respond well to ‘conservative treatment’. He said The COVID-19 Subcommittee of Who is the Global Advisory Committee on Vaccine Safety in a statement.

causal link

According to the data in US Vaccine Adverse Event Reporting System, approximately 40.6 cases of myocarditis per million second doses among males, and 4.2 cases per million among females, as of June 11, 2021, were reported in those 12-29 years of age who received COVID-19 mRNA vaccines.

For people over 30 years of age, the reporting rates were 2.4 and 1.0 per million second doses, respectively, for males and females.

These conditions occur more often in younger men and after the second dose of the vaccine, usually within a few days after the vaccination. Current evidence suggests a possible causal relationship between myocarditis and mRNA vaccines,” the WHO panel wrote, noting that Pharmacovigilance Risk Assessment Committee The European Medicines Agency, confirmed plausible causation.

According to the experts, more rigorous studies are underway using alternative data sources and more robust study designs, and they will continue to review the situation as more data becomes available.

Guidance for patients and doctors

According to WHO experts, vaccinated individuals should be directed to seek immediate medical care if they develop symptoms indicative of myocarditis or pericarditis such as new chest pain, persistent pain, shortness of breath or palpitations after vaccination.

Physicians should also be aware of the risk of developing myocarditis and pericarditis with mRNA vaccines and of those most at risk.

They should be alert for any acute chest pain, shortness of breath, and palpitations that may indicate post-vaccination myocarditis, especially in adolescents or young adults. Coronary events are unlikely to be a source of such symptoms among young adults.

“Where possible, suspected cases should be evaluated, guidelines provided and followed up with a consultation with a cardiologist,” they noted, adding that it is also important to rule out other potential causes of cases, including COVID-19 infection and other causes due to a viral infection.

Recognizing the clear benefits of mRNA vaccines in reducing mortality and hospitalization due to COVID-19 infection, the Subcommittee encouraged all health professionals to report all myocarditis and other adverse events observed with these and other vaccines.


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