Beyond the CBD: Here comes the other hemp, but where’s the evidence? Harvard Health Blog


Within a few years, he was A component of hemp called CBD (CBD) went from being a relatively obscure molecule to a healthcare fad that has swept the world, generating billions in sales, millions of users, CBD workout clothes, pillowcases, hamburger, ice cream – you name it. The concerns of such a rapid adoption are that enthusiasm could rise above the actual science, and that there are safety issues, such as Drug interaction, Which is given short enthusiasm for treatment Chronic painInsomnia, anxiety and many other conditions that CBD is believed to help alleviate.

However, hemp is made up of about 600 different molecules, about 140 of which are called hemp because they act on the endocannabinoid system in our bodies – a broad system of chemical transmitters and receptors that help control many of our most important bodily systems such as appetite, inflammation, temperature, and emotional processing. Memory and learning. It was only a matter of time until new cannabinoids were discovered and commercialized.

What are some of these newer cannabinoids, and what evidence they may help us?

Unfortunately, much of the data on these newly discovered compounds comes from animal studies, so it will take time – and high-quality research – to determine whether the benefits found in animals will apply to humans.


CBG, or cannabigerol, is a non-toxic cannabinoid marketed to relieve anxiety, pain, infection, inflammation, nausea and even treat cancer. It has a wide variety of potential medicinal uses, but nearly all studies in it have been conducted in animals, so it is difficult to extrapolate completely to humans. Experiments with mice have shown this to be possible Reducing inflammation associated with inflammatory bowel diseaseAnd it can slow down the growth of colorectal cancer. In cells Inhibits glioblastoma cells (The type of brain cancer Senator John McCain suffered from).

CBG has also been shown to act as an antimicrobial against many different agents, including the hard-to-treat MRSA that causes many hospital-acquired infections. Additionally, CBG is an appetite stimulant, and it may help treat bladder spasms. Currently, one of the main risks in using it is the lack of regulation and standardization that accompanies the entire supplement industry in this country, so it is not always guaranteed that you are getting what you think you are getting – and this is true for all of the materials discussed in this post.


THCV or tetrahydrocannabivarin is potentially exciting because it may support efforts to treat obesity and the diabetes epidemic. There is strong animal data reporting lowering insulin levels during fasting, facilitating weight loss, and improving blood sugar control. at The 2016 study Posted in Diabetes care, THCV has been shown to significantly improve fasting glucose, and the function of pancreatic beta cells (the cells that make insulin that ultimately fail in diabetes), as well as many other hormones associated with diabetes. In both animals and humans, it has been well tolerated without major side effects. In places like Israel, where the study of cannabinoids is much more advanced than in the United States, strains that contain high levels of cannabinoids such as THCV (and low levels of THC) are grown so that they can be studied.


CBN cannabinoids, or cannabinoids, are present in trace amounts in the hemp plant, but it is mainly a by-product of the degradation of THC. Long-sitting marijuana is famous for becoming “sleepy old marijuana” – allegedly due to the high CBN concentrations in it, although there are other plausible explanations for the phenomenon. CBN is widely marketed for its calming and sleep-stimulating properties, but if you check the literature it’s interesting to note. There is practically no scientific evidence That CBN makes you sleepy, except for one study in mice that were already on barbiturates, who slept longer when CBN was added. This isn’t to say that CBN doesn’t make people sleepy – as many people claim – just because it hasn’t been scientifically established yet.

Usually with the claims about hemp, there is Some The evidence is, at least in animal studies, to support it. However, CBN does have the potential (despite only animal studies to date) to act as an appetite stimulant and anti-inflammatory agent – both of which are critically important medicinal uses, if present in humans. A recent study from Israel In humans, they showed that higher cannabinoid strains on CBN were associated with better control of ADHD symptoms. We need more human studies before science can support marketing claims about CBN’s benefits.


Delta-8-THC is found in trace amounts in cannabis, but it can be distilled and made from hemp. It is increasingly marketed as Medical Marijuana with a Little Ecstasy And the less anxiety that can come with this euphoria. Unlike the other compounds discussed here, Delta-8-THC is being An intoxicating hemp, but it contains only a fraction of the euphoria caused by THC – and much less of the accompanying anxiety and paranoia. It can relieve many of the same symptoms that cannabis can cause, making it an attractive potential drug for people who only want a little cannabis intake. It is thought to be especially beneficial for nausea and stimulating appetite. there Some evidence (Albeit from a very small study in 10 children) suggests that delta-8-THC may be an effective option for preventing vomiting during cancer chemotherapy. While the Delta 8 claims are interesting, there is a lack of good human studies to prove its effectiveness or safety, so we need to treat marketing claims with caution.

There is a renewed interest in cannabis research

With the increasing acceptance of medical cannabis – currently, 94% of Americans support legal access to medicinal cannabis The one thing nearly everyone agrees on is the need for more research into hemp and hemp: their benefits, harms, and ways in which we can safely develop and use them to improve human health. We’re in the midst of an incredibly exciting time, with new discoveries happening daily in cannabis science, and I’m keen to see what the future holds. However, just as we have learned from our experiences with CBD, we need to be patient and filter our enthusiasm through the quiet lens of science. Most of all, we need to be smart consumers who can find the real benefits amid the complexity of political agendas and the marketing allegations that seem to accompany all things cannabis related.


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